Organ Defender

Vitamin C (as Ascorbic Acid)

Vitamin C is perhaps historically best-known for the treatment and prevention of scurvy, though it has many other roles in the body. For example, vitamin C catalyzes or is a cofactor in eight enzymatic reactions involved in the synthesis of collagen, the nutrient carnitine, and several neurotransmitters necessary for the proper function of the brain. In contemporary context, vitamin C is best known as a potent antioxidant. In addition to its intrinsic activity as an antioxidant, vitamin C has been shown in in vitro trials to regenerate alpha-tocopherol (vitamin E). As an antioxidant, vitamin C combats the detrimental effects of a group of compounds called radical oxygen species that, when produced, degrade the lipid membrane of the cell and may cause internal damage. By “scavenging” these free radicals, vitamin C and other antioxidants form a defense against excess cellular damage.

Iodine (as Kelp (Ascophyllum Nodosum))

Iodine is a trace element naturally present in certain foods, including kelp. Iodine is a critical component for fetal development, especially during early pregnancy, as maternal T4 (thyroxine) is the sole source of fetal thyroid hormone. After birth, especially if breast-feeding, iodine remains an important constituent of a balanced diet to maintain adequate T3 (triiodothyronine) and T4 (thyroxine) levels in the mother and for proper cognitive development in the child. As implied, however, the most important of iodine’s functions is assisting the body’s production and maintenance of both thyroid hormones and TSH (thyroid stimulating hormone, released by the pituitary). The thyroid hormones, in turn, regulate several critical biochemical reactions, including protein synthesis, and, along with norepinephrine/epinephrine, largely determine the body’s metabolic rate. In addition to these benefits for the thyroid, iodine can also be a critical element for women’s health. About 70% of the body’s iodine is concentrated in the tissues of the brain, immune system, ovaries, uterus, breasts, and prostate gland (in men). Being this close to the female reproductive system, iodine also has a large effect on ovulation and estrogen. Iodine is believed to reduce ovulation pain, prevent ovarian cysts, and boost progesterone levels when there is too much estrogen present, which can cause heavy menstruation, breast pain, fibroids, and premenstrual irritability. Iodine can also help reduce estrogen-related side effects in two ways: by promoting healthy detoxification of estrogen and by making cells less sensitive to estrogen.

Selenium (as Albion® Selenium Glycinate Complex)

Selenium is a trace element that is naturally found in many foods but is often seen added to others, as well as available as a dietary supplement. It possesses a high nutritional benefit for humans as it is a constituent of more than two dozen selenoproteins that play critical roles in reproduction, thyroid hormone metabolism, DNA synthesis, and protection against cellular damage. Selenium glycinate is a highly bioavailable form of selenium. It avoids food and other minerals that compete for absorption in the gut, which allows it to have enhanced absorption in the gastrointestinal tract. Selenium has also been studied for its prostate cancer reduction benefits in men. Selenium supplementation was shown to increase activity for erythrocyte and plasma glutathione peroxidase as well as lowered values for plasma prostate specific antigens. This antioxidant activity noticed from selenium can allow it to be of high benefit to those suffering from prostate cancer or at risk of developing prostate cancer.

N-Acetyl L-Cysteine

N-Acetyl Cysteine (NAC) is a powerful antioxidant and precursor to glutathione, known as the body's master antioxidant. Playing a crucial role in reducing oxidative stress, NAC can aid in the detoxification of harmful substances, as well as support the body’s immune function. By replenishing the body’s intracellular glutathione levels, NAC can enhance cellular defense against free radicals, which may contribute to longevity and resilience against age-related decline. Additionally, NAC can support respiratory health by breaking down mucus and improving lung function, making it beneficial for conditions like chronic bronchitis. Its role in modulating glutamate levels also provides neuroprotective benefits, potentially aiding cognitive function and mental health. Additionally, NAC has been studied for its ability to improve insulin sensitivity and support metabolic health, making it a promising compound for overall wellness and performance.

Red Yeast Rice Powder (grain)

Red yeast rice is traditional Asian preparation of the rice grain with an extensive history dating back to 300 BC. The rice is fermented in a culture of yeast called Monascus purpureus, which transfers in bright red coloration to the white rice grains. In part due to its centuries of use in traditional Chinese medicine, red yeast rice is widely recommended in regimens intended to help establish normal cardiac function and lipid profiles. More recent studies suggest the fungal metabolites found within red yeast rice demonstrate a positive impact on cholesterol and cardiac function. Specifically, a fungal secondary metabolite found within red yeast rice, known as monacolin K, has been shown to of particular interest. The primary mechanism of action of monacolin K is inhibition of the key enzyme, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, involved in cholesterol synthesis. Upon further evaluation of the lipid lowering properties of red yeast rice, recent research revealed them to be multifactorial, including the ability to downregulate the rate limiting step of hepatic cholesterol biosynthesis in a dose-dependent manner, indirectly cause an upregulation or availability of LDL-receptors in the liver, and possibly increase the hepatic excretion of bile acids, thereby creating an increased need for the availability of intrahepatic cholesterol for use in the synthesis of additional bile. The reduced intrahepatic cholesterol concentrations result in the upregulation or availability of LDL-receptors in the liver. The purpose of these additional LDL-receptors is to pull cholesterol out of circulation and bring it into the liver as a replacement for the reduced production inside the liver. When this happens, the plasma cholesterol levels will decrease through a reduction in the hepatic synthesis of cholesterol and through an increase in the removal of circulating cholesterol from blood plasma into the liver for use. These actions can help restore cholesterol levels to where they benefit cardiac and other bodily functions. Note: If you are taking other statins or other cholesterol lowering medication, please consult with your physician prior to supplementing with ORGAN DEFENDER.

Hawthorn Berry Extract (fruit) (4:1) (Crataegus pinnatifida Bunge) (Fruit)

Hawthorne has been utilized for many centuries for its wide range of health benefits. One of these primary benefits is how it positively affects the cardiovascular system. The berries, or fruit, of the plant contain high amounts of bioflavonoids and proanthocyanidins, substances shown to contain most of the health promoting qualities. These antioxidants have several mechanisms of action on the cardiovascular system. Hypotensive (lowering blood pressure) improvements can be seen through vasorelaxation through the stimulation of nitric oxide production. Several studies have investigated this benefit on blood pressure as well. One human study conducted on individuals with high blood pressure showed that the administration of 1200mg of Hawthorn Berry (slightly more than what we use in this product), noticed substantial improvements in blood pressure when compared to placebo. Hawthorne Berry can also play a role in preventing atherosclerosis, or a buildup of plaque in the blood vessels that occurs due to an imbalance in blood fat levels (typically high triglycerides and low HDL cholesterol). If this plaque continues to accumulate, it can lead to blockages in the blood vessels carrying blood to vital organs, ultimately resulting in heart attack or stroke. Anti-atherosclerotic improvements can be seen through the downregulation of capsase-3 gene expression. The capsase-3 gene is known for being a proapoptotic (cell killing) gene that has been reported in heart failure and myocardial infarction (heart attack). The regulation of lipoprotein lipase (regulates the delivery of fats to body tissues) expression and raised excretion of bile acids can also benefit the arteries. Several animal studies have examined the positive impact of Hawthorne Berries on cholesterol. One study on mice showed that mice given the extract resulted in a lower total and LDL cholesterol, as well as between 30-45% lower liver triglyceride levels compared to mice that were not administered the extract. On cardiac cells, these antioxidants downregulate capsase-3 gene expression and inhibit 3’,5’-cyclic adenosine monophosphate phosphodiesterase, which can result in an increase in coronary flow, increase in relaxation velocity, and cause a positive inotropic effect (increase the strength of heart muscle contraction).

Bacopa monnieri Extract (whole herb) (std. 50% Bacosides)

Bacopa monnieri, also known as the water hyssop commonly, or as Brahmi in Ayurvedic texts, is a small creeping herb endemic to sub-tropical India. The herb has been used in traditional Indian medicine for well over one thousand years, with its first recorded usage coming in the 6th century A.D. In this traditional context, BM has been used for a wide range of purposes, including as a treatment of asthma and epilepsy. More recently, BM has been the subject of numerous cognition and memory trials, as the plant has a well-established nootropic effect. Likely through modulation of the serotonin reuptake system, clinical trials in healthy humans have demonstrated that BM possesses a significant effect on the retention of newly learned information. In several trials utilizing a 300mg daily serving, BM was also shown to decrease the recall delay of newly learned information and reduce short term forgetfulness – suggesting that the herb’s effect on the serotonic and cholinergic systems are increasing the encoding (the literal storing) of memory information.

Milk Thistle Extract (Silybum marianum) (Seed) (std. 80% Silymarin)

Silybum marianum, also known as milk thistle, is a medicinal thistle from the aster or daisy family that has been used in traditional medicines for many centuries for treatment of many different diseases. Many of these treatments have been to protect the liver and associated organs from damage/further damage. There is evidence to support that milk thistle, and specifically the silymarin compound that is found within it, exhibits a mechanism of action for hepatoprotection from free radicals through antioxidant activity, enhanced protein synthesis, and possible anti-inflammatory or immunomodulating effects. These free radicals are generated through the damage to cellular membranes called lipoperoxidation. Additionally, silymarin also enhances liver glutathione production through the inhibition of hepatocyte glutathione reduction. This can further contribute to the antioxidant support and defense for the liver. Several studies have shown improvements in liver function in individuals with certain liver diseases leading to these proposed benefits. In one in vitro human study, silymarin was shown to inhibit T-cell proliferation and proinflammatory cytokine secretion in a dose-dependent manner. Higher doses of silymarin were shown to specifically control hepatic inflammation responses in chronic liver diseases. It is important to note that in relation to liver diseases, milk thistle has been studied as a complimentary treatment method for traditional treatments and that it is important to live a healthy lifestyle to prevent these diseases as much as possible.

Grape Seed Extract (Vitis vinifera) (Seed) (std. 95% Proanthocyanidins)

Grape seed extract is a potent source of oligomeric proanthocyanidins (OPCs), which are known for their strong antioxidant and anti-inflammatory properties. These polyphenols can help neutralize free radicals, reducing oxidative stress and supporting overall cardiovascular health by improving endothelial function and promoting healthy blood flow. Studies suggest that grape seed extract can enhance nitric oxide production as well, contributing to better circulation and potentially optimizing exercise performance. Additionally, its anti-inflammatory effects may aid in joint health and recovery by reducing markers of inflammation. Grape seed extract has also been shown to support cognitive function by protecting neurons from oxidative damage and improving blood flow to the brain as well as enhance skin health through collagen stabilization and UV protection makes it a valuable ingredient for overall wellness and longevity.

Grape Seed Extract (Vitis vinifera) (Seed) (std. 95% Proanthocyanidins)

Grape seed extract is a potent source of oligomeric proanthocyanidins (OPCs), which are known for their strong antioxidant and anti-inflammatory properties. These polyphenols can help neutralize free radicals, reducing oxidative stress and supporting overall cardiovascular health by improving endothelial function and promoting healthy blood flow. Studies suggest that grape seed extract can enhance nitric oxide production as well, contributing to better circulation and potentially optimizing exercise performance. Additionally, its anti-inflammatory effects may aid in joint health and recovery by reducing markers of inflammation. Grape seed extract has also been shown to support cognitive function by protecting neurons from oxidative damage and improving blood flow to the brain as well as enhance skin health through collagen stabilization and UV protection makes it a valuable ingredient for overall wellness and longevity.

Marigold Extract (Flower) (5% Lutein)

Marigold extract, primarily derived from Tagetes erecta and Calendula officinalis, is rich in carotenoids such as lutein and zeaxanthin, which play a crucial role in eye health. By filtering harmful blue light and reducing oxidative stress in the retina, these compounds have been linked to a lower risk of age-related macular degeneration and improved visual performance. Additionally, marigold extract possesses potent anti-inflammatory and antioxidant properties, which can contribute to overall skin health by promoting collagen production and reducing UV-induced damage. Marigold extracts bioactive flavonoids and triterpenoids also support immune function by modulating inflammatory pathways and enhancing the body’s natural defense mechanisms. Research suggests that marigold extract may also aid cognitive function by reducing neuroinflammation and oxidative stress in the brain. Together, these benefits make marigold extract a valuable botanical for overall wellness, longevity, and protection against age-related decline.

Saw Palmetto Extract (Serenoa repens) (Fruit)

Saw Palmetto is a traditional herb that grows in the Southern coastal regions of the United States that has been often used to maintain normal, healthy prostate function. Growth of the prostate is believed to happen through the action of 5α-reductase, which catalyzes the conversion of testosterone to dihydrotestosterone. Dihydrotestosterone binds to nuclear androgen receptors and activates the transcription of androgen-regulated genes that are mitogenic to both epithelial and stromal cells. Since the development and growth of the prostate gland depend on androgen stimulation, the mechanisms of action of saw palmetto include several antiandrogenic effects, such as inhibition of 5α-reductase I and II and inhibition of binding of dihydrotestosterone (DHT) to the cytosolic androgen receptors, anti-proliferative effects and anti-inflammatory effects. Several studies have shown that saw palmetto, and the mechanisms of action listed above, may positively influence the prostate by helping to maintain its optimal size and function, which then equates to a healthy urinary flow and frequency.

Co-Q-10 (Ubiquinone)

Coenzyme Q10, which is synthesized in the mitochondrial inner membrane, is an essential compound that plays many vital roles in the human body. Of these many roles, it is a key component in the electron transport chain in mitochondria necessary for ATP production. CoQ10 can also act as an intercellular antioxidant, protecting the plasmatic membrane against peroxidation. CoQ10 deficiency has been associated with less-than-optimal health status in organisms and has contributed to certain degenerative states involving blood sugar, the cardiovascular system, and musculoskeletal system. In relation to the cardiovascular system, oxidative stress is one of the main causes of cardiac decline. The antioxidant properties of CoQ10 are of particular importance in establishing normal function. It has been shown that individuals suffering from cardiac related abnormalities have significantly lower levels of CoQ10 as opposed to those with higher levels. With antioxidant effect and free radical neutralization being the primary mechanism of action, CoQ10 exhibits a secondary mechanism of action of well in playing a large role in the heart’s energetic needs. The process of cardiac contraction requires the release of Ca2+ from the SR, and the following activation of the contractile proteins requires energy. It is believed that when there is myocardial failure, it is caused by a reduction in the production of energy from the mitochondria. This goes back to CoQ10s, the property of being a main component in the transport of electrons that are needed for ATP production. These two mechanisms of action have a particular importance for one’s quality of life as well as in maintaining proper cardiovascular function.

Zeaxanthin 10%

Zeaxanthin is a powerful carotenoid antioxidant primarily known for its role in ocular health, particularly in protecting the macula of the eye from oxidative damage caused by blue light and environmental stressors. As one of the two dominant macular pigments, alongside lutein, zeaxanthin can enhance visual acuity and contrast sensitivity while reducing the risk of age-related macular degeneration and cataracts. Its potent antioxidant properties further extend beyond eye health, contributing to cognitive function by mitigating oxidative stress and inflammation in neural tissues, which are highly susceptible to free radical damage. Additionally, zeaxanthin supports cardiovascular health by reducing lipid peroxidation and improving endothelial function, which can enhance blood flow and overall vascular integrity. Research also suggests a role in skin health, as zeaxanthin helps protect against UV-induced oxidative damage, promoting skin elasticity and reducing signs of aging. Through these mechanisms, zeaxanthin serves as a critical nutrient for maintaining overall wellness, longevity, and optimal cellular function.

Probiotic Blend (L. acidophilus, L.casei, L. salivarius, L. plantarum, L. brevis, B. bifidum, S. thermophilus, B. lactic/longum, L. rhamnosus)

A well-functioning gut and microbiome is usually a result of what is introduced to its environment. Probiotics, beneficial bacteria that play a crucial role in maintaining overall health by supporting gut microbiome balance, are also linked to improved digestion, enhanced nutrient absorption, and a stronger immune system. Probiotics can help crowd out harmful bacteria and pathogens, reducing the risk of infections and gastrointestinal issues like bloating, diarrhea, and constipation. They also can contribute to mental well-being by having a positive influence on the gut-brain axis, potentially reducing stress and improving mood. Studies suggest probiotics may also support heart health by lowering cholesterol and blood pressure while promoting metabolic health by aiding in weight management and blood sugar regulation. If you are looking for a simple and effective way to enhance overall vitality, incorporating probiotics through supplements or fermented foods can be an easy way to do so.

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